Reduction of delta-aminolevulinate dehydratase concentration by bromobenzene in rats.
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منابع مشابه
Downregulation of delta‐aminolevulinate dehydratase is associated with poor prognosis in patients with breast cancer
Delta-aminolevulinate dehydratase (ALAD) catalyzes the second step in the biosynthesis of heme and is also an endogenous inhibitor of the 26S proteasome. The role of ALAD in breast cancer progression is still unclear. In this study, we found that the expression of ALAD was downregulated in breast cancer tissues compared with adjacent normal breast tissues. Enhanced ALAD expression was associate...
متن کاملEffects of aluminum sulfate on delta-aminolevulinate dehydratase from kidney, brain, and liver of adult mice.
The purpose of the present study was to investigate the in vitro and in vivo effects of aluminum sulfate on delta-aminolevulinic acid dehydratase (ALA-D) activity from the brain, liver and kidney of adult mice (Swiss albine). In vitro experiments showed that the aluminum sulfate concentration needed to inhibit the enzyme activity was 1.0-5.0 mM (N = 3) in brain, 4.0-5.0 mM (N = 3) in liver and ...
متن کاملHighly heterogeneous nature of delta-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria.
The properties of 9 delta-aminolevulinate dehydratase (ALAD) mutants from patients with ALAD porphyria (ADP) were examined by bacterial expression of their complementary DNAs and by enzymologic and immunologic assays. ALADs were expressed as glutathione-S-transferase (GST) fusion proteins in Escherichia coli and purified by glutathione-affinity column chromatography. The GST-ALAD fusion protein...
متن کاملEnzymic glycation may decrease activity of erythrocytic delta-aminolevulinate dehydratase in diabetes mellitus.
The mean dithiothreitol (DTT)-activated activity of erythrocytIc -aminolevulinate dehydratase (ALAD,EC 4.2.1.24, porphobilinogen synthase) in 20 nondiabetic subjects was 30.5 (SD 4.0) U per liter of erythrocytes; in 79 diabetics, this activity was 19.4 (SD 6.3) U/L, significantlyless (P <0.001). Further, we observed a significant (P <0.01) negative correlation between activated ALAD activity an...
متن کاملInfluence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.
delta-Aminolevulinate dehydratase (ALAD) is the second enzyme in the heme biosynthesis pathway. ALAD is a zinc metalloenzyme, and its inhibition by lead substitution for zinc is one of the most sensitive indicators of blood-lead accumulation, a measure of recent lead exposure. Stoichiometry calculations indicate that a significant portion of blood lead is stored in ALAD. Human ALAD exhibits a c...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1988
ISSN: 1351-0711
DOI: 10.1136/oem.45.9.640